Purpose: This study is done to identify how a clinical practice orientation program would affect anxiety, self-esteem and self-efficacy in college students in nursing. Method: Data was collected from 127 nursing students in February, 2008. The collected data were analyzed with the SPSS/Win 12.0 program, using t-test, ANOVA, paired t-test and Pearson's correlation coefficients. Results: The total mean scores were; anxiety 53.22/80, self-esteem 29.51/40 and self-efficacy in 59.76/85. Self-esteem and self-efficacy level were significantly different according to the level of Fundamentals practice and satisfaction with nursing as a major satisfaction(p=.001). The effect of the orientation program on clinical practice were a significantly increased in self-esteem and self-efficacy (p=.000). But in terms of anxiety, the effect was the opposite. So study to identify other factors causing anxiety and strategies to reduce the anxiety need to be considered. Conclusion: It is important to improve self-esteem and self-efficacy and the study results indicate that an orientation program is one strategy that needs to be developed to meet these needs for college students in nursing.
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